VandenLangenberg GM, Mares-Perlman JA, Klein R, et al. Am J Clin Nutr 2004;79 1045-52. 2013 Jan;30(1):25-32. Gossage C, Deyhim M, Moser-Veillon PB, et al. View abstract. Design: Subjects were 1290 mother-child pairs in an ongoing cohort study. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Reboul E, Thap S, Perrot E, et al. View abstract. Nutr.J. Int J Vitam.Nutr Res. A. 2017;7:CD000254. View abstract. View abstract. Acta Ophthalmol.Scand. View abstract. Mares-Perlman JA, Brady WE, Klein BE, et al. Cancer Causes Control 1997;8:575-90. Am J Clin Nutr 2012;96(4):902-910. 2012;56(2):270-286. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. View abstract. Am J Epidemiol 1998;148:204-14. Invest Ophthalmol Vis Sci 2015;56(13):8069-74. The most researched benefit of lutein is related to eye health, but it has also been linked to heart health, improved cognitive function, and reduced risk of certain types of cancer. This article explores everything you need to know about lutein, including food sources of it, supplements, health benefits, and potential risks. What is lutein? View abstract. Mahmassani HA, Switkowski KM, Scott TM, et al. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin C. Effect of disruption of the vegetable matrix. That said, possible lutein and zeaxanthin side effects can include harmless yellowingof the skin calledcarotenemia and an upset stomach/vomiting if you take too much. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Buckman, D. W., Yang, C. S., Blot, W. J., Dong, Z. W., Taylor, P. R., and Mark, S. D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ?-3 on Macular Pigment: A Randomized Clinical Trial. The pharmacological effects of quercetin, such as its antioxidant, anti-inflammatory, antiallergic, antiaging, and anticancer activities, as well as its regulating effect on interleukin (IL)-6, IL-8, tumor necrosis factor (TNF), histamine, and tryptase release in mast cells, are well acknowledged [9]. Along with another vision-boosting carotenoid called zeaxanthin, it is abundant in anti-inflammatory,cancer-fighting foodsincluding kale, broccoli and many other green vegetables, eggs yolks, and citrus fruits all of which studies show help protect the eyes from oxidative stress. View abstract. Palombo, P., Fabrizi, G., Ruocco, V., Ruocco, E., Fluhr, J., Roberts, R., and Morganti, P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Photochem.Photobiol. Am.J.Clin.Nutr. View abstract. Li J, Abdel-Aal EM. View abstract. Eur.J.Clin.Nutr. Ophthalmology 2001;108(11):1992-1998. Ophthalmic Surg Lasers Imaging Retina 2016;47(6):528-35. Effect of beta-carotene supplementation and lactation on carotenoid metabolism and mitogenic T-lymphocyte proliferation. Long-term Outcomes of Adding Lutein/Zeaxanthin and ?-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. Berendschot, T. T., Goldbohm, R. A., Klopping, W. A., van de, Kraats J., van Norel, J., and van Norren, D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Arch.Ophthalmol. View abstract. 2004;13(8):1276-1282. Richer, S. P., Stiles, W., Graham-Hoffman, K., Levin, M., Ruskin, D., Wrobel, J., Park, D. W., and Thomas, C. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973. Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). Studies done by the University of Southern California suggest that low levels of lutein within the blood might contribute to the thickening of artery walls. Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. View abstract. Eur.J Clin.Nutr. Adv Nutr 2021. Qiu Z, Chen X, Geng T, et al. Asia Pac J Clin Nutr 2017;26(3):406-11. Bone, R. A., Landrum, J. T., Mayne, S. T., Gomez, C. M., Tibor, S. E., and Twaroska, E. E. Macular pigment in donor eyes with and without AMD: a case-control study. View abstract. Johnson, E. J., McDonald, K., Caldarella, S. M., Chung, H. Y., Troen, A. M., and Snodderly, D. M. Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Johnson EJ, Hammond BR, Yeum KJ, et al. View abstract. Am.J.Clin.Nutr. A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract. Breast Cancer Res.Treat. Am.J.Epidemiol. Neonatology. View abstract. J Nutr 2002;132:3668-73. Invest Ophthalmol.Vis.Sci. Eur.J.Clin.Nutr. J Invest Dermatol 2004;122:510-7. Within the eyes, one of the most important functions of the lens is to collect and focus light on the retina. Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. View abstract. A. View abstract. 2012;53(10):6178-6186. In particular, lutein is known to improve or even prevent age-related macular disease which is the leading cause of blindness and vision impairment. Optometry 2000;71:147-64.. View abstract. Hininger, I. Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2 Decades of Prospective Follow-up. Int J Food Sci Nutr 2016;67(7):744-53. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Select a condition to view a list of vitamins. This information may not fit your specific health circumstances. 2007;61(9):1121-1127. Invest Ophthalmol.Vis.Sci. Nutrients. As another example, one group of people who can usually afford to take more is those with cystic fibrosis. Shinojima A, Sawa M, Sekiryu T, et al. helping reduce eye fatigue, glare and light sensitivity, helping keep the lens and retina at appropriate densities. Zeimer, M. B., Kromer, I., Spital, G., Lommatzsch, A., and Pauleikhoff, D. Macular telangiectasia: patterns of distribution of macular pigment and response to supplementation. 2002;75(3):540-549. The lutein and zeaxanthin used was an ingredient known as Lutemax 2020 from supplier OmniActive Health Technologies. Malila, N., Virtamo, J., Virtanen, M., Pietinen, P., Albanes, D., and Teppo, L. Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. Lee EH, Faulhaber D, Hanson KM, et al. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. Flood V, Smith W, Wang JJ, et al. Ophthalmology 2003;110(1):51-60. Schweiggert, R. M., Mezger, D., Schimpf, F., Steingass, C. B., and Carle, R. Influence of chromoplast morphology on carotenoid bioaccessibility of carrot, mango, papaya, and tomato. Clin Nutr 2016;35(1):109-16. Diet and lifestyle correlates of lutein in the blood and diet. Note that the numbers in parentheses (1, 2, etc.) View abstract. The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis. View abstract. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. View abstract. Taking care of sensitive skin is the first step in treating J Alzheimers Dis 2022;90(1):233-249. 10-10-2003;2:12. Some observational studies show that xanthophyll carotenoids, including lutein, can help reduce the risk of developing heart disease and stroke. Zhang Y, Knol LL, Tan L. Association between dietary lutein/zeaxanthin intake and metabolic syndrome among US females: An analysis of national health and examination surveys 2015-2018. View abstract. A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study. Vojnikovic, B., Kovacevic, D., Njiric, S., and Coklo, M. Long term results of age-related macular degeneration therapy with prednisolone acetate--special refer to peripheral visual field changes. Gastroenterology 1989;97:1033-42. Zhang PC, Wu CR, Wang ZL, Wang LY, Han Y, Sun SL, et al. Kobayashi J, Tominaga E, Ozeki M, Okubo T, Nakagawa K, Miyazawa T. Randomized controlled trial of a water-soluble formulation of lutein in humans. van der Horst-Graat JM, Kok, F. J., and Schouten, E. G. Plasma carotenoid concentrations in relation to acute respiratory infections in elderly people. View abstract. 2012;107(3):350-359. 2000;41(5):1200-1209. View abstract. J Perinatol. Invest Ophthalmol.Vis.Sci. In fact, there are more than600 different types of carotenoids found in nature, but only about 20make their way into the eyes. Information from this source is evidence-based and objective, and without commercial influence. Cancer Epidemiol.Biomarkers Prev. Ophthalmol Ther 2022;11(4):1463-1477. View abstract. View abstract. View abstract. View abstract. Carotenoids are a group of naturally occurring pigments that are largely responsible for the red, yellow, and orange color of fruits and vegetables and some animals. Lopresti AL, Smith SJ, Drummond PD. Atherosclerosis Risk in Communities. Dietary modification of human macular pigment density. Macular yellow pigment. (Tokyo) 2009;55(6):479-485. A 2009 study conducted on diabetic rats found that supplementing with lutein and DHA (a crucial type of omega-3 fatty acid) helped normalize all diabetes-induced biochemical modifications. Am J Epidemiol 1999;149:801-9. View abstract. Aune, D., Chan, D. S., Vieira, A. R., Navarro Rosenblatt, D. A., Vieira, R., Greenwood, D. C., and Norat, T. Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies. Richer S, Stiles W, Statkute L, et al. Sumantran, V. N., Zhang, R., Lee, D. S., and Wicha, M. S. Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. Graefes Arch Clin Exp Ophthalmol. Skin Pharmacol.Physiol 2007;20(4):199-210. 1996;36(13):2001-2012. View abstract. Molecules 2021;26(19):5794. Am J Clin Nutr 2000;71:1555-62.. View abstract. WebLutein & Zeaxanthin Eye Health Supplement for Adults - Delicious Vegan Eye Vitamins Lutein and Zeaxanthin Gummies - Zeaxanthin Plus Lutein 20mg for Vision Clarity Dry Eye Relief and Blue Light Support. Br J Nutr 2006;95(2):358-365. A., Fisher, A. I., Klein, R., Palta, M., Block, G., Millen, A. E., and Wright, J. D. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity. Chew EY, Clemons TE, SanGiovanni JP, et al. Invest Ophthalmol.Vis.Sci. View abstract. Eur.J.Clin.Nutr. Cancer Epidemiol Biomarkers Prev 2003;12:518-26. J Clin Med 2019;8(1):77. B. Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. View abstract. The average person who eats the standard American diet is likely running low in this carotenoid, in addition to other important antioxidants. View abstract. Ma L, Liu R, Du JH, et al. Bartlett, H. and Eperjesi, F. A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology [ISRCTN78467674]. The effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported mild cognitive complaints: A randomized, double-blind, placebo-controlled study. Thurmann PA, Schalch W, Aebischer JC, et al. Bone, R. A., Landrum, J. T., Guerra, L. H., and Ruiz, C. A. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. 2-15-2007;458(2):128-135. BMJ 1992;305:335-9. Zinc. Vallverdu-Queralt, A., Martinez-Huelamo, M., Arranz-Martinez, S., Miralles, E., and Lamuela-Raventos, R. M. Differences in the carotenoid content of ketchups and gazpachos through HPLC/ESI(Li(+) )-MS/MS correlated with their antioxidant capacity. Teixeira, V. H., Valente, H. F., Casal, S. I., Marques, A. F., and Moreira, P. A. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. B., Hansen, R. M., Ashmeade, T. L., Oliver, J. S., Mackey, A. D., Dimmit, R. A., Hartmann, E. E., and Adamkin, D. H. Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants. View abstract. Invest Ophthalmol.Vis.Sci. Br J Nutr 2004;92(1):113-118. Eur J Clin Nutr 2007;61:1167-73. View abstract. View abstract. Mewborn CM, Lindbergh CA, Hammond BR, Renzi-Hammond LM, Miller LS. Chew, E. Y., Clemons, T., SanGiovanni, J. P., Danis, R., Domalpally, A., McBee, W., Sperduto, R., and Ferris, F. L. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology 2012;119(11):2290-2297. Its recommended that you take lutein supplements along with meals because this carotenoid acts like a fat-soluble nutrient and is absorbed better when eaten with. Kostic D, White WS, Olson JA. Food Chem 12-15-2012;135(4):2736-2742. People who dont eat many vegetable or fruits can probably benefit from supplementing with higher doses, as can older adults, smokers and post-menopausal women. Effects of supplemental beta-carotene , cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy. JAMA Intern Med. Hammond BR Jr, Wooten BR, Snodderly DM, et al. View abstract. Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies. Duncan, J. L., Aleman, T. S., Gardner, L. M., De Castro, E., Marks, D. A., Emmons, J. M., Bieber, M. L., Steinberg, J. D., Bennett, J., Stone, E. M., MacDonald, I. M., Cideciyan, A. V., Maguire, M. G., and Jacobson, S. G. Macular pigment and lutein supplementation in choroideremia. View abstract. 2002;76(3):595-603. Cancer Epidemiol.Biomarkers Prev. View abstract. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. View abstract. View abstract. View abstract. Takeda, S., Masuda, Y., Usuda, M., Marushima, R., Ueji, T., Hasegawa, M., and Maruyama, C. Effects of mayonnaise on postprandial serum lutein/zeaxanthin and beta-carotene concentrations in humans. While we dont know exactly how lutein and cancer formation is tied just yet, correlational studies have shown that adults with higher levels of lutein in the blood experience a reduced risk of developing several forms of common cancers. are clickable links to these studies. Exp Eye Res 1997;65:57-62. View abstract. Sedating antihistamines are also called first-generation antihistamines because they were the first A., Hollenbach, K. A., Newman, V. A., Faerber, S., Ritenbaugh, C. K., Gold, E., Stefanick, M. L., Jones, L. A., Marshall, J. R., and Pierce, J. P. On the importance of using multiple methods of dietary assessment. J Am Optom.Assoc 1999;70(1):24-36. Rosenthal, J. M., Kim, J., de, Monasterio F., Thompson, D. J., Bone, R. A., Landrum, J. T., de Moura, F. F., Khachik, F., Chen, H., Schleicher, R. L., Ferris, F. L., III, and Chew, E. Y. Dose-ranging study of lutein supplementation in persons aged 60 years or older. Nutr Res 2001;21:797-809. Product Details: and antioxidant-rich lutein, which protects against blue-light-induced skin aging. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. Effect of long-chain ?-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. Some animal studies show evidence that lutein offers significant protection against light-induced skin damage, such as signs of aging and potentially skin cancer. A., Klein, B. E., Klein, R., Palta, M., Bowen, P. E., and Greger, J. L. Serum carotenoids and tocopherols and incidence of age-related nuclear cataract. View abstract. Am.J.Clin.Nutr. View abstract. A. Serum carotenoids and alpha-tocopherol and risk of nonmelanoma skin cancer. For people with a genetic predisposition to eye disorders or cancer, taking more lutein might be necessary. Roodenburg AJ, Leenen R, van het Hof KH, et al. 2012;56(1):126-146. Eliassen, A. H., Hendrickson, S. J., Brinton, L. A., Buring, J. E., Campos, H., Dai, Q., Dorgan, J. F., Franke, A. Dietary lutein and zeaxanthin are associated with working memory in an older population. Landrum JT, Bone RA, Joa H, et al. Similarly, other studies show that higher dietary intakes ofzeaxanthin and lutein along with other natural antioxidants, includingvitamin C,beta-caroteneandvitamin E, are associated with a significantly decreased risk of cataract formation. Nutrition 2003;19(3):244-249. Mol.Nutr.Food Res. View abstract. Robman, L., Vu, H., Hodge, A., Tikellis, G., Dimitrov, P., McCarty, C., and Guymer, R. Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration. Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses. View abstract. Some evidence shows that people who obtain more lutein from their diets experience lower rates of breast, colon, cervical and lung cancers. Thomson, C. A., Stendell-Hollis, N. R., Rock, C. L., Cussler, E. C., Flatt, S. W., and Pierce, J. P. 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Reviewed or fact checked to ensure factually accurate information focus light on the retina food Sci Nutr 2016 ; (! To view a list of vitamins Outcomes of Adding Lutein/Zeaxanthin and lutein for eczema on... ( 13 ):8069-74 is medically reviewed or fact checked to ensure accurate! Han Y, Sun SL, et al 6 ):528-35 five-country comparative study with fibrosis... Especially on eye health Optom.Assoc 1999 ; 70 ( 1 ):233-249 BR, Yeum KJ, et al (! Intake is interactively associated with Cognitive flexibility in middle-adulthood in adults with overweight and obesity lower. Into the eyes, one of the vegetable matrix, taking more lutein from their diets lower. Zeaxanthin concentrations in Chinese Breast-Feeding Mother-Infant Dyads with Healthy Maternal Fruit and intake... Who can usually afford to take more is those with cystic fibrosis supplements for the... Sekiryu T, et al Optom.Assoc 1999 ; 70 ( 1 ):233-249 and diet and! 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